The innovators:
Ervin Balázs (25%) horticultural engineer, molecular biologist, plant virologist, biotechnologist, academician,
Ákos Gellért (25%) chemist, senior research fellow in structural biology, biomolecular modelling, bioinformatics, and virology
Katalin Salánki (25%) scientific advisor in plant virology,
Tamás Tuboly (25%) veterinarian, immunologist. He received his doctorate from the University of Veterinary Science in 1986. After graduating from university, he worked as a laboratory veterinarian at the National Animal Health Institute, then spent 13 years conducting research at the Hungarian Academy of Sciences’ Veterinary Medical Research Institute. He was invited to join the Department of Epidemiology and Microbiology as an associate professor, where he has been conducting extensive teaching and research work as a university professor since 2011. (Source: Hungarian Veterinary Pantheon in Hungarian)
Reporting institutions: Agricultural Biotechnology Research Centre (23.6%), Hungarian Academy of Sciences Agricultural Research Centre (43.8%), Szent István University (32.6%)
Description: “The subject of the invention is a recombinant porcine circovirus vaccine (PCV) containing recombinant CMV capable of producing virions in plants containing recombinant CMV, wherein the recombinant CMV coat protein (CP) of the recombinant CMV contains one or more epitopes of the PCV coat protein (CP). The invention is suitable for controlling PCV-related infections in mammals, particularly in pig herds.”
(Source and source of the image: P 1100470 : Nanopartikulomokon alapuló állatorvosi vakcina : Közzétételi leírás. 18 p. URL: http://epub.hpo.hu/e-kutatas/?lang=HU# )
Year: 30.08.2011 (Published in 2013)
Interesting: The inventors had two publications in Hungarian papers. The source of the summary below is the following article:
Tombác Kata, Salánki Katalin, Gellért Ákos, Tuboly Tamás, Balázs Ervin: Az állat-egészségügyi célú vakcina-előállítás lehetőségei növények felhasználásával : Irodalmi áttekintés. Magyar Állatorvosok Lapja, 2012. 134. 12. 751–762. p.
”Widespread and targeted use of specific vaccines is an essential tool of the prevention and control of infectious diseases in the veterinary practice. Vaccine development went through a spectacular reform during the last decades and one potential direction of this progress is the use of antigens produced in plants for vaccination purposes. The authors provide a summary of the results of this field, about the already accomplished and the expected research and development courses. Antigen expression in plants is a promising possibility for subunit vaccine production. To date, many immunogenic proteins of veterinary importance have been expressed in transgenic plants or using plant virus vectors. Among the advantages of plant expression systems are the possibility of inexpensive production and the potential of oral vaccine application, as well.”
The other article: Tombácz Kata – Gellért Ákos – Salánki Katalin – Balázs Ervin – Tuboly Tamás: Oral immunogenicity of a plant virus vector based porcine circovirus antigen – short communication. Acta veterinaria Hungarica, 2013. 61. 4. 547–552. p.
